Peanuts, Pills, and Progress: The AR101 Breakthrough

In this episode, we dive into the fascinating world of oral immunotherapy (OIT) and explore the efficacy and safety of AR101 (now known as PTAH)—a groundbreaking treatment designed to reduce the risk of severe allergic reactions in children and adolescents with peanut allergy.

We unpack the science behind this novel therapy, discuss key clinical trial findings (including the pivotal PALISADE study), and explore what AR101 means for families living with the daily anxiety of accidental peanut exposure. Along the way, we reflect on the balance between desensitisation and quality of life, and what clinicians and caregivers need to consider when navigating this evolving landscape.

Whether you’re a healthcare professional, allergy researcher, or parent of a child with food allergies, this episode offers insights into a new era in allergy treatment—one peanut at a time.

Sources:

1. Vickery, B.P., Vereda, A., Casale, T.B., Beyer, K., Du Toit, G., Hourihane, J.O., Jones, S.M., Shreffler, W.G., Marcantonio, A., Zawadzki, R., Dilly, S.G., Adelman, D.C. and Burks, A.W. (PALISADE Group of Clinical Investigators) (2018) 'AR101 Oral Immunotherapy for Peanut Allergy', The New England Journal of Medicine, 379(21), pp. 1991-2001. doi: 10.1056/NEJMoa1812856.
2. Fernandez-Rivas, M., Vereda, A., Vickery, B.P., Sharma, V., Nilsson, C., Muraro, A., Hourihane, J.O.B., DunnGalvin, A., Du Toit, G., Blumchen, K., Beyer, K., Smith, A., Ryan, R., Adelman, D.C. and Jones, S.M.(2022) 'Open-label follow-on study evaluating the efficacy, safety, and quality of life with extended daily oral immunotherapy in children with peanut allergy', Allergy, 77(3), pp. 991–1003. doi: 10.1111/all.15027.
3. Bajzik, V., DeBerg, H.A., Garabatos, N., Rust, B.J., Obrien, K.K., Nguyen, Q., O’Rourke, C., Smith, A., Walker, A.H., Quinn, C., Gersuk, V.H., Farrington, M., Jeong, D., Vickery, B.P., Adelman, D.C. and Wambre, E. (2022) 'Oral desensitization therapy for peanut allergy induces dynamic changes in peanut-specific immune responses', Allergy, 77(8), pp. 2534–2548. doi: 10.1111/all.15276.

Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.

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