Nasal Adrenaline: A Game-Changer for Anaphylaxis Care?

Severe allergic reactions can happen anywhere, anytime — and every second counts. In this episode, we explore the exciting new development of adrenaline nasal spray (Neffy) as a potential needle-free treatment for anaphylaxis. Could this innovation improve how quickly lifesaving medication is delivered? Could it reduce hesitation, fear of injections, and treatment delays?

Join us as we break down:

• How adrenaline nasal spray works in the body
• Safety, ease of use, and real-world benefits
• Differences vs. traditional adrenaline auto-injectors (e.g., EpiPen)
• What this could mean for patients, carers, schools, and emergency responders
• The future of anaphylaxis management and allergy care

Whether you’re a clinician, parent, educator, or someone living with severe allergies, this episode helps you stay ahead of the latest advances in food allergy and anaphylaxis treatment — all in clear, accessible language.

You can listen now to discover how a simple nasal spray could become a lifesaving revolution in allergy emergencies.

Sources:

1. Chen, J., Chilampalli, et al. (2019). A Phase 1, Single-Dose, Open-Label, 5-Treatment, Crossover, Pharmacokinetic Study of Comparative Bioavailability of Epinephrine Nasal Spray and EpiPen® in Healthy Adults With Seasonal Allergies. J Allergy Clin Immunol, February 2019, AB144 Abstracts.
2. Crescioli, G., et al. (2025). Epinephrine nasal spray for the treatment of anaphylaxis: perspectives in pediatrics. Curr Opin Allergy Clin Immunol, 25(6), pp. 511–517. doi: 10.1097/ACI.0000000000001109.
3. Dribin, T.E., et al. (2025). Intranasal epinephrine: The need to have confidence in efficacy. Journal of Allergy and Clinical Immunology, doi: 10.1016/j.jaci.2025.07.023.
4. Ellis, A.K., Casale, et al. (2024). Development of neffy, an Epinephrine Nasal Spray, for Severe Allergic Reactions. Pharmaceutics, 16(811). doi: 10.3390/pharmaceutics16060811.
5. FDA Approves First Epinephrine Nasal Spray (2024). AJN, 124(12), p. 16.
6. Fleischer, D.M., et al. (2025). Pharmacokinetics and Pharmacodynamics of neffy, Epinephrine Nasal Spray, in Pediatric Allergy Patients. J Allergy Clin Immunol Pract, 13(6), pp. 1335–1341. doi: 10.1016/j.jaip.2025.03.019.
7. Golden, D.B.K., Greenhawt, M. & Shaker, M.S. (2025). Prescribing nasal epinephrine spray: Confidence limits with novel treatments. J Allergy Clin Immunol, 156(614-5), pp. 614–615. doi: 10.1016/j.jaci.2025.06.008.
8. Greenhawt, M., et al. (2024). Pharmacokinetic and Pharmacodynamic Profile of Epinephrine Nasal Spray Versus Intramuscular Epinephrine Autoinjector in Healthy Adults. J Allergy Clin Immunol Pract, 12(12), pp. 3274–3282. doi: 10.1016/j.jaip.2024.10.006.
9. Treudler, R., et al. (2025). Adrenaline nasal spray in emergency management: An initial expert opinion. Allergologie select, 9, pp. 80–85. doi: 10.5414/ALX02590E.

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Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.

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